FoundMyFitness

Dale E. Bredesen

Dale E. Bredesen, M.D., is a professor of neurology at the Easton Laboratories for Neurodegenerative Disease Research at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA).

Dr. Bredesen's laboratory focuses on identifying and understanding basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective treatments for Alzheimer's disease and other neurodegenerative conditions. He has collaborated on the publication of more than 220 academic research papers.

In this episode, we discuss:

  • 00:00 - Introduction
  • 06:00 - What is Alzheimer's disease?
  • 09:29 - Alzheimer's types - hot, dry, and toxic
  • 18:56 - APOE-4 gene triples risk of Alzheimer's disease
  • 20:55 - Cognoscopy for dementia detection
  • 23:11 - Lifestyle interventions
  • 32:33 - Keto flex 12/3 diet can treat dementia
  • 50:58 - Omega-3s resolve inflammation
  • 57:39 - Sauna use detoxifies the body 
  • 01:06:05 - Available consumer tests

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/dale-bredesen

Join over 300,000 people and get the latest distilled information on alzheimer's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: dale_bredesen_1.mp3
Category:general -- posted at: 8:20pm EST

Dr. Valter Longo

Dr. Longo is the current director of the longevity institute at the University of Southern California and also director of the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy.

Dr. Longo’s research focuses understanding the biological mechanisms that regulate the aging process, the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases.

In this episode, we discuss...

  • 00:00 - Introduction
  • 09:30 - Defining fasting
  • 16:10 - Insulin/growth hormone axis and aging
  • 21:37 - Growth hormone deficiency protects from some diseases
  • 30:55 - Fasting vs a ketogenic diet for cancer
  • 40:13 - The fasting-mimicking diet (FMD)
  • 48:28 - "Yo-yo" fasting once per month
  • 52:21 - Fasting does not reduce muscle mass 
  • 57:03 - Autophagy and apoptosis are our repair mechanisms
  • 01:02:33 - Refeeding is necessary to rebuild healthy cells
  • 01:05:31 - Top 5 biomarkers of healthy aging

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/valter-longo-2

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: longo_2.mp3
Category:general -- posted at: 11:18am EST

Charles Raison

Charles Raison, M.D. is a professor at the School of Human Ecology at the University of Wisconsin-Madison and Founding Director of the Center for Compassion Studies in the College of Social and Behavioral Sciences at the University of Arizona.

Dr. Raison’s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the effect of heat stress as a potentially therapeutic intervention major depressive disorder.

In this episode, you'll discover:

  • 00:00 - Introduction
  • 06:26 - Role of inflammation in depression
  • 10:08 - Evolutionary mechanism
  • 16:19 - Genetics of depression
  • 22:57 - How obesity causes depression biochemically
  • 33:32 - Does exercise treat depression
  • 36:08 - Hyperthermia as treatment
  • 46:08 - Inflammation promotes depression
  • 53:39 - Did we evolve to need hormetic stress?
  • 01:03:38 - Heat-shock proteins
  • 01:06:10 - Repurposing ancient wisdom
  • 01:17:31 - Psychedelics and meditation
  • 01:27:51 What is the role of conventional pharmacotherapy?
  • 01:35:19 - Lifestyle modifications for depression
  • 01:42:21 - Why light and circadian rhythm are important for mental health

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/charles-raison

Join over 300,000 people and get the latest distilled information on depression straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: charles_raison_1.mp3
Category:general -- posted at: 4:15pm EST

1