In this interview Dr. Rhonda Patrick talks to Dr. Frans Kuypers about his lab’s discovery on how the human placenta is a rich source of pluripotent stem cells and yet the placenta is thrown away after delivery. They discuss how his lab has shown that the stem cells from the placenta can be transformed into neuron-like cells, fat cells, bone cells, endothelial cells (relevant for lung and blood vessels), and liver cells. His lab also developed a technique for harvesting 5 to 7 times more hematopoietic stem cells from placenta than is currently retrieved from cord blood, a more standard, established source that is used worldwide for bone-marrow transplant.

Direct download: frans_kuypers_1.mp3
Category:general -- posted at: 8:01pm EDT

In this podcast, I interview Dr. George A Brooks, an expert in exercise physiology and lactate metabolism. Lactate, a once demonized molecule thought to form lactic acid and become a dead-end toxic metabolite, has been vindicated by the work of Dr. Brooks, his colleagues, and others. Lactate has been shown not be the cause of muscle fatigue, but to actually be a source of energy itself, even being metabolized greedily with a greater degree of preference than many other more well-known sources of energy, such as glucose. Recent research has demonstrated that this lactate metabolism pathway has a very special importance in situations of traumatic brain injury, which is an area of inquiry that Dr. Brooks has recently been involved with researching and we talk a little bit about during this interview.

Direct download: george_brooks_1.mp3
Category:general -- posted at: 6:45pm EDT

Dr. Rhonda Patrick discusses the differences between krill oil and fish oil in terms of bioavailability and transport into different cells. She explains how DHA and EPA from fish oil in ethyl ester form (molecularly distilled) is the least bioavailable due. She also explains why omega-3 fatty acids in phospholipid from from krill oil are more bioavailable than EPA and DHA in triglyceride form from fish oil. She talks about the differences in transport of DHA into the brain and why krill oil has a type of DHA (DHA in phosphatidylcholine) that is more readily transported into the brain because it forms DHA-lysophsophatidylcholine. She talks about astaxanthin, a carotenoid that is unique to krill oil, and has potent antioxidant activity and prevents the oxidation of DHA and EPA.

Direct download: why_krill_oil_beats_fish_oil.mp4
Category:general -- posted at: 7:23am EDT

Dr. Rhonda Patrick explains what antioxidants are, why they are important, and how they prevent DNA damage, a well-known cancer initiator, in order to minimize damage to DNA. 

However, in the context of someone that already has cancer, DNA damage can activate genes that kill cancer cells. Dr. Patrick also reveals there are two major forms of vitamin E (alpha and gamma tocopherol) that have separate functions. Taking mega doses (i.e. 400 IU/day) of alpha tocopherol actually DEPLETES gamma tocopherol levels and has negative effects that may lead to prostate cancer.

Direct download: antioxidants_cancer.mp4
Category:general -- posted at: 6:20pm EDT

Dr. Terry Wahls' Protocol That Reversed Multiple Sclerosis

In this video Dr. Rhonda Patrick interviews Dr. Terry Wahls about how she reversed her secondary-progressive multiple sclerosis with a micronutrient-dense diet and Paleo principles. She identified vitamins/minerals and other compounds present in vegetables/fruits that are essential for mitochondrial health, which is critical for brain function.

Direct download: drwahls.mp4
Category:general -- posted at: 1:00am EDT

Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" causes adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and muscle mass (by boosting levels of heat shock proteins and growth hormone). She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.

Direct download: hyperthermic-conditioning.mp4
Category:general -- posted at: 8:25pm EDT

A talk originally delivered at SF Nerd Nite that discusses the interesting world of epigenetics.Dr. Rhonda Patrick talks about how to hack your genes through diet and lifestyle. Transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation revering neurodegenerative disease, exercise increases neurogenesis, and vitamin D controls aging.

Direct download: hack-genes-sfnerdnite.mp4
Category:general -- posted at: 4:22pm EDT

In this podcast we discuss and critically analyze a recent headline-grabbing editorial that was published in the Annals of Internal Medicine that reviewed three studies on the topic of multivitamins and chronic disease prevention. We analyze the important shortcomings of the studies and talk about the mechanism.

Direct download: rebuttal-antivitamin.mp4
Category:general -- posted at: 6:06am EDT