FoundMyFitness

In this nearly 2.5-hour episode, Dr. Rhonda Patrick and Dr. Roger Seheult and Kyle Allred of MedCram make a thoughtful, merit-based, and truly comprehensive discussion of COVID-19 vaccination.

In addition to being a co-founder of MedCram Medical Lectures, Dr. Roger Seheult is, as you will find out in the conversation, a boots on the ground, critical care pulmonologist.

For Dr. Seheult, COVID-19 is not just theory. He sees real sick people and for that reason brings a very special context to this conversation. Furthermore, Dr. Seheult is also an academic and educator. He is an Associate Clinical Professor at the University of California, Riverside School of Medicine and an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple-board certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine and Sleep Medicine through the American Board of Internal Medicine.

In this episode, we discuss:

  • 00:00:00 - Introduction
  • 00:06:58 - Vaccination in the young and healthy
  • 00:12:25 - Risk of myocarditis from COVID-19 is greater than for vaccination
  • 00:16:18 - Long-haul COVID is often preceded by mild infection
  • 00:25:36 - The spike protein generated from vaccination is not the same as the viral one
  • 00:34:16 - Biodistribution of vaccine particles
  • 00:41:17 - COVID-19 Vaccine Adverse Event Reporting System (VAERS)
  • 01:06:55 - Antibody-dependent enhancement isn't a concern for the SARS-CoV-2 vaccine
  • 01:14:54 - Do the COVID-19 vaccines damage human fertility?
  • 01:19:51 - Can mRNA vaccines alter human DNA?
  • 01:28:10 - Current ivermectin evidence
  • 01:47:40 - Delta-variant and breakthrough infections
  • 02:01:42 - Viral evolution (virulence vs. immune escape)
  • 02:10:45 - T-cell immunity vs. antibody immunity

Watch the annotated video:
https://www.youtube.com/watch?v=pp-nPZETLTo

Subscribe to MedCram on Apple Podcasts:
https://podcasts.apple.com/us/podcast/medcram/id1564795918

Subscribe to MedCram on YouTube:
https://www.youtube.com/channel/UCG-iSMVtWbbwDDXgXXypARQ

Direct download: MedCram_COVID_19_master.mp3
Category:general -- posted at: 5:35pm EST

Dr. William ("Bill") Harris is one of the world's preeminent experts in the field of omega-3 fatty acid research. His work has focused on the roles that fatty acids in play in cardiovascular and neurocognitive health.

The author of more than 300 scientific papers on fatty acids and health, Dr. Harris is a professor in the Department of Medicine in the Sanford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute.

In this episode, Dr. Harris and I discuss…

  • 00:00:00 - Introduction
  • 00:06:36 - Early studies on omega-3s, dietary fats, and cholesterol 
  • 00:14:44 - Omega-3s may normalize bleeding times 
  • 00:20:33 - Plant-based omega-3s are not equivalent in power to marine omega-3s 
  • 00:25:23 - Genetic engineering of plants is needed for sustainable omega-3s in the future
  • 00:27:18 - The omega-3 index reveals individual variations in omega-3 needs
  • 00:32:13 - Red blood cell concentration of omega-3s better reflect long-term omega-3 status
  • 00:36:41 - Genetic variants influence omega-3 dietary needs
  • 00:54:20 - The omega-3 index may predict life expectancy
  • 01:05:03 - How metabolites of omega-3 reduce and resolve inflammation
  • 01:17:11 - High omega-3 concentrations halve the risk of COVID-19 death
  • 01:20:10 - DHA may help keep the SARS-CoV-2 spike protein from entering cells
  • 01:22:50 - Concerns over the omega-6/omega-3 ratio may be unfounded

Looking for more? 

Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Direct download: bill_harris_public.mp3
Category:general -- posted at: 6:15pm EST

Dr. Ashley Mason is a clinical psychologist and director of the Sleep, Eating, and Affect Laboratory at the Osher Center for Integrative Medicine at UCSF. Her research centers on nonpharmacological approaches for treating depression, insomnia, and overeating.

In this episode, we discuss:

  • 00:00:00 - Introduction
  • 00:08:10 - Whole-body hyperthermia (WBH) and sauna use differ
  • 00:17:06 - Depression causes thermoregulatory dysfunction – but sauna use may correct it
  • 00:21:12 - WBH and sauna use may reduce symptoms of depression
  • 00:33:22 - Heating the body slowly may improve heat tolerance and increase WBH effectiveness
  • 00:39:35 - Sauna use may benefit people with depression and cardiovascular disease – which often coincide
  • 00:40:18 - Dr. Mason and Rhonda are collaborating on new research on depression and WBH
  • 00:44:19 - Sauna bathing and similar practices often provide opportunities for people to connect socially
  • 00:53:12 - Common causes of insomnia
  • 01:01:26 - Cognitive behavioral therapy, sleep hygiene, stimulus control, and sleep restriction for treating insomnia

Looking for more? 

Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: Mason_Public_LibSyn.mp3
Category:general -- posted at: 6:22pm EST

Dr. Mark Mattson

Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature.

Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting.

In this episode, we discuss...

  • 00:3:31 - Hormetic stressors drive adaptation and prevent physiological complacency
  • 00:13:00 - Intermittent fasting improves health by promoting metabolic switching
  • 00:16:49 - Daily time-restricted eating vs 5:2 weekly fasting 
  • 00:27:44 - A ketogenic diet and intermittent fasting differ in terms of brain effects
  • 00:34:23 - Exercising while intermittent fasting exerts additive effects
  • 00:52:32 - Plant-based bioactive compounds induce hormetic stress
  • 01:10:48 - Severe caloric restriction may compromise muscle mass
  • 01:26:25 - Intermittent fasting in young vs. old and in men vs. in women
  • 01:35:20 - The effects of cortisol differ during a fast versus chronic stress
  • 01:53:36 - Fasting-mimetics like resveratrol and spermidine vs actual fasting
  • 02:08:44 - How ketone supplementation may improve brain health

Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: mark_mattson_1.mp3
Category:general -- posted at: 2:24am EST

Dr. Satchin Panda

Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. 

Dr. Panda’s work focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches. He is an expert on circadian rhythms and a pioneer in the field of time-restricted eating. A priority for Dr. Panda when designing his studies is to identify strategies that positively impact public health.

In this episode, Dr. Panda and I discuss...

  • 00:00:00 - Introduction
  • 00:04:29 - How circadian rhythms influence human health
  • 00:12:30 - Seeking bright light in the morning and avoiding it in the evening improves sleep
  • 00:20:40 - Supplemental melatonin may counteract evening bright light exposure
  • 00:26:16 - The relationship between melatonin and insulin secretion 
  • 00:33:15 - Shift work, jet lag, and modern life contribute to circadian dysfunction
  • 00:45:10 - Naps might aid with afternoon sleepiness and sleep loss
  • 00:47:05 - Indoor lighting can be used to promote healthy circadian rhythms
  • 00:51:20 - Time-restricted eating strengthens circadian biology
  • 01:02:13 - Dr. Panda’s ongoing study uses a smartphone app to track diet
  • 01:03:41 - Most people are unaware of their eating patterns
  • 01:07:58 - How Dr. Panda incorporates his research findings into his own life
  • 01:16:21 - Our circadian rhythms dictate when we should exercise

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/satchin-panda-3

Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: satchin-panda-clubhouse_iTunes_AUPH.mp3
Category:general -- posted at: 7:16pm EST

Michael Snyder

Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics.

In this episode, we discuss:

  • 00:00:00 - Introduction
  • 00:12:51 - Continuous glucose monitor use in people without diabetes
  • 00:31:04 - A smartwatch helped diagnose Dr. Snyder's Lyme disease
  • 00:34:00 - Predicting other illnesses with smartwatches
  • 00:40:41 - Detecting airborne pollutants in the exosome 
  • 00:51:04 - Genetics and metabolism tell us our Ageotypes
  • 00:58:05 - Exercise is most important for longevity
  • 01:03:11 - Dr. Snyder's lifestyle habits

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/michael-snyder

Join over 300,000 people and get the latest distilled information on personalized medicine straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: synder-final-audio_AUPH.mp3
Category:general -- posted at: 5:29pm EST

Dr. Roger Seheult
Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity.
 
What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic.

In this episode, we discuss:

  • 00:00:00 - Introduction
  • 00:06:20 - How MedCram Videos got started 
  • 00:09:37 - Using evidence to make COVID-19 treatment decisions
  • 00:12:46 - The differences in treating early vs late-stage COVID-19 
  • 00:14:40 - How doctors would've treated COVID-19 one-hundred years ago
  • 00:18:13 - Increasing ventilation reduces SARS-CoV-2 transmission 
  • 00:20:28 - Masks are virtually universally beneficial regardless of type
  • 00:21:32 - Vitamin D and COVID-19
  • 00:22:22 - Steroid chemical structure of vitamin D 
  • 00:23:24 - The vitamin D RDA is likely too low
  • 00:24:23 - Vitamin D is more like a hormone than vitamin
  • 00:26:21 - The overlap between COVID-19 and vitamin D deficiency
  • 00:30:27 - How Mendelian randomization studies helped solve the vitamin D puzzle
  • 00:34:20 - The gene regulatory effects of vitamin D 
  • 00:35:49 - Vitamin D and the ACE2/renin-angiontensin system
  • 00:42:00 - Daily doses of vitamin D are more effective 
  • 00:43:23 - A prescription-only form of vitamin D (calcifediol) may be best for COVID-19
  • 00:47:06 - Skin synthesis of vitamin D from sunlight can be unreliable 
  • 00:53:43 - The safest dose range for vitamin D
  • 01:06:15 - The beneficial circadian effect of early morning sunlight
  • 01:07:38 - Sleep deprivation impairs vital immunity
  • 01:12:08 - Dr. Seheult's suggestions for the best sleep
  • 01:19:18 - A Spanish flu era treatment boosts interferon by ten times
  • 01:22:38 - Why interferon is so important for the viral response
  • 01:26:43 - Treating the symptoms of fever during the Spanish flu harmed patients
  • 01:31:58 - Dr. Seheult's ongoing research of hot hydrotherapy 
  • 01:47:00 - COVID-19 Vaccines

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/roger-seheult

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: seheult_1.mp3
Category:general -- posted at: 3:42pm EST

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