FoundMyFitness

Steve Horvath

Steve Horvath, PhD, is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health

Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/steve-horvath

Join over 300,000 people and get the latest distilled information on aging straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


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Direct download: Steve-Horvath_final.mp3
Category:general -- posted at: 12:44pm EDT

Dr. Jed Fahey

In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.

 

In this episode, you'll discover:

  • 00:07:19 - The minimum daily dose of sulforaphane that elicits beneficial health effects
  • 00:12:04 - Why gauging the amount of sulforaphane in foods presents challenges
  • 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods
  • 00:23:38 - How often to consume broccoli sprouts and how long their effects last
  • 00:39:28 - The effects of sulforaphane on glutathione production in the brain
  • 00:43:12 - The effects of sulforaphane on cancer
  • 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends)
  • 01:33:08 - Safety concerns regarding sulforaphane

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/jed-fahey-q-a

Join over 300,000 people and get the latest distilled information  straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: jed_fahey_2.mp3
Category:general -- posted at: 7:35pm EDT

Giselle Petzinger

Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.

Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.

 

In this episode, you'll discover:

  • 00:06:57 What is Parkinson’s disease?
  • 00:11:57 How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1
  • 00:14:57 How other circuits in the brain can compensate for the loss of function of the substantia nigra.
  • 00:18:37 Prevalence and hereditary risk factors of Parkinson’s disease. 
  • 00:21:25 How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1 
  • 00:26:57 How exercise can lower the risk of developing Parkinson’s disease. 1 2 3
  • 00:35:38 How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space.
  • 00:47:49 How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2 
  • 00:58:33 How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1
  • 01:01:31 Why exercise may not fully replace the use of medications.
  • 01:09:58 How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4
  • 01:12:12 How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/giselle-petzinger

Join over 300,000 people and get the latest distilled information on parkinson's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Direct download: giselle_petzinger_1.mp3
Category:general -- posted at: 4:35pm EDT

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This collection of clips covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, purported health benefits, and when and how to break the fast.

 

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: Fasting_Aliquot_NON-Members_1_AUPHONIC.mp3
Category:general -- posted at: 6:18pm EDT

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

 

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: Sauna_Aliquot_NON-Members_1_AUPHONIC.mp3
Category:general -- posted at: 3:15pm EDT

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As.

Just for a few examples, it covers...

  • My pre-pregnancy regimen, including diet, exercise, vitamins and sleep
  • Nutrition for babies and toddlers to maximize brain development and growth
  • Extra precautions that I took during my pregnancy
  • And much, much more!

 

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: aliquot-001-preg-dev.mp3
Category:general -- posted at: 5:42pm EDT

This episode aims to be the most comprehensive video compendium on the biology of breast milk ever recorded.

In this episode, you'll discover:

  • 00:07:11 - Breast milk composition and production
  • 00:09:59 - Human milk oligosaccharides in breast milk establish the infant gut microbiome
  • 00:15:48 - Omega-3 fatty acids and other components in breast milk boost brain development
  • 00:18:14 - Vitamins and minerals in breast milk
  • 00:22:05 - Breast milk stem cells and multi-organ microchimerism
  • 00:22:54 - Harmful substances transferred to infant via breast milk
  • 00:28:03 - The effects of breastfeeding on the infant's immune system
  • 00:31:17 - Effects on intelligence
  • 00:34:36 - Breastfeeding as a benefit to maternal health

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/breast-milk

Join over 300,000 people and get the latest distilled information on the biology of breast milk straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Direct download: breastmilk.mp3
Category:general -- posted at: 4:38pm EDT

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things.

In this episode, you'll discover:

  • 00:04:03 Data surrounding SARS-CoV-2 duration
  • 00:06:37 SARS-CoV-2 and potential immunity
  • 00:11:35 Some of the main factors known to play a role in immune variation
  • 00:12:05 What role genetics may play in immune function
  • 00:14:27 How previous viral exposure regulates immunity
  • 00:15:05 What cross immunity is and how it may be relevant for SARS-CoV-2
  • 00:19:46 Antibody-dependent enhancement and SARS-CoV-2 relevance
  • 00:21:50 How sleep is a key regulator of immune function
  • 00:23:44 Microbiome composition and immune function
  • 00:28:31 The differential effects of exercise intensity and duration on immune regulation
  • 00:35:00 How specific micronutrient inadequacies may promote immune dysregulation
  • 00:47:20 The effect of sex hormones on immune function
  • 00:48:55 How biological age age may play a role in immune regulation
  • 00:49:46 Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
  • 00:53:15 ARDS and long-term lung damage

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/covid-19-episode-2

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: covid19_qa_2.mp3
Category:general -- posted at: 4:58pm EDT

In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

In this episode, you'll discover:

  • 00:07:33 - Background on vitamin C
  • 00:17:09 - Bioavailability of vitamin C [including dosing frequency]
  • 00:22:53 - Vitamin C in the context of the common cold
  • 00:28:09 - Vitamin C and lung function
  • 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation]
  • 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity
  • 00:48:44 - Vitamin C and the brain 
  • 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection
  • 00:55:33 - Intravenous Vitamin C and cancer
  • 00:57:40 - Effect of Vitamin C on fertility and reproduction
  • 00:58:36 - Intravenous vitamin C and cardiovascular health
  • 01:00:42 - Vitamin C and inflammation
  • 01:02:38 - Vitamin C’s mechanisms of action 
  • 01:08:34 - Intravenous and Oral vitamin C safety
  • 01:10:20 - Vitamin C intake and kidney stone risk
  • 01:13:57 - Conclusions

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/vitamin-c

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: vitamin_c.mp3
Category:general -- posted at: 11:48am EDT

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon. 

In this episode, you'll discover:

  • 00:02:36 Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?
  • 00:11:00 Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?
  • 00:17:58 Can you talk about quercetin's role as a zinc ionophore? 
  • 00:20:51 Is there any indication blood type influences COVID-19 risk?
  • 00:24:52 Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?
  • 00:43:45 Can you discuss whether sauna use might help prevent COVID19?
  • 00:52:55 Is it true that high dose intravenous vitamin C might help treat COVID-19?
  • 01:04:35 What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/covid-19-episode-1

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: covid19_qa_1.mp3
Category:general -- posted at: 5:30pm EDT

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, you'll discover:

  • 00:08:00 - Omega-3
  • 00:27:23 - Metformin
  • 00:50:05 - Sulforaphane
  • 01:06:57 - Magnesium L-Threonate
  • 01:13:44 - Sauna
  • 01:23:48 - New FMF Membership

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/rhonda-krs-2

Join over 300,000 people and get the latest distilled information on sulforaphane research straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

 

Direct download: krs_rhonda_2.mp3
Category:general -- posted at: 5:31pm EDT

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