FoundMyFitness

Steve Horvath

Steve Horvath, PhD, is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health

Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.

In this episode, we discuss:

  • 00:00 - Introduction and overview
  • 20:24 - Horvath Aging Clocks
  • 26:36 - Heredity determines aging
  • 35:49 - DNAm PhenoAge vs GrimAge
  • 45:58 - Slowing the epigenetic clock
  • 01:10:43 - Epigenetics: Cause or consequence of aging?
  • 01:16:43 - Vitamin D reverses epigenetic age
  • 01:19:07 - Omega-3 slows GrimAge clock
  • 01:24:19 - Ongoing research

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/steve-horvath

Join over 300,000 people and get the latest distilled information on aging straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


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Direct download: Steve-Horvath_final.mp3
Category:general -- posted at: 12:44pm EST

Dr. Jed Fahey

In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.

In this episode, we discuss: 

  • 00:00:00 - Introduction
  • 00:07:19 - The minimum daily dose of sulforaphane 
  • 00:12:04 - Gauging sulforaphane content of foods is challenging
  • 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods
  • 00:23:38 - How often to consume broccoli sprouts and how long their effects last
  • 00:39:28 - The effects of sulforaphane on glutathione production in the brain
  • 00:43:12 - The effects of sulforaphane on cancer
  • 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends)
  • 01:33:08 - Safety concerns regarding sulforaphane

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/jed-fahey-q-a

Join over 300,000 people and get the latest distilled information  straight to your inbox weekly: https://www.foundmyfitness.com/newsletter


Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: jed_fahey_2.mp3
Category:general -- posted at: 7:35pm EST

Giselle Petzinger

Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.

Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.

In this episode, we discuss:

  • 00:00:00 - Introduction
  • 00:06:57 - What is Parkinson’s disease?
  • 00:11:57 - When symptoms of Parkinson’s disease appear 
  • 00:14:57 - Circuits in the brain can compensate for  substantia nigra dysfunction
  • 00:18:37 - Hereditary risk factors of Parkinson’s disease
  • 00:21:25 - Parkinson’s disease is associated with pesticide and pollutant exposure
  • 00:26:57 - Exercise can lower the risk of developing Parkinson’s disease
  • 00:35:38 - How skill-based exercise such as boxing reduces disease symptoms 
  • 00:47:49 - Treadmill exercise increased BDNF and brain health
  • 00:58:33 - Exercise at 80 percent of maximum heart rate slowed Parkinson’s disease progression 
  • 01:01:31 - Why exercise may not fully replace medications 
  • 01:09:58 - DHA reduces motor symptoms and dyskinesia 
  • 01:12:12 - Patients with Parkinson’s disease have higher levels of inflammatory biomarkers

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/giselle-petzinger

Join over 300,000 people and get the latest distilled information on parkinson's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

 

Direct download: giselle_petzinger_1.mp3
Category:general -- posted at: 4:35pm EST

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

In this previous, you'll learn:

  • 00:01:48 - Fasting supports a healthy gut microbiome and reduces autoimmunity
  • 00:08:28 - Increasing autophagy with fasting 
  • 00:13:26 - Reducing protein acetylation with fasting mimetics
  • 00:18:17 - Fasted exercise, water fasting, and a fasting-mimicking diet

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: Fasting_Aliquot_NON-Members_1_AUPHONIC.mp3
Category:general -- posted at: 6:18pm EST

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

In this episode, you'll learn:

  • 00:01:41 - Evidence supporting sauna use for health
  • 00:04:09 - How Finnish humid saunas can reduce viral illness
  • 00:08:40 - Sauna and hot bath use during the COVID-19 pandemic
  • 00:15:07 - Rhonda's sauna routine

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: Sauna_Aliquot_NON-Members_1_AUPHONIC.mp3
Category:general -- posted at: 3:15pm EST

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As.

In this episode, you'll hear:

  • 00:00:00 - Introducing "The Aliquot"
  • 00:02:43 - Omega-3s for babies and toddlers to maximize brain development
  • 00:07:02 - Common nutrient deficiencies in children and how to prevent them
  • 00:11:42 - Evidence to support omega-3 supplementation in children
  • 00:20:58 - Fasting considerations and restrictions for women

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: aliquot-001-preg-dev.mp3
Category:general -- posted at: 5:42pm EST

This episode aims to be the most comprehensive video compendium on the biology of breast milk ever recorded.

In this episode, you'll discover:

  • 00:00:00 - Introduction
  • 00:07:11 - Breast milk production and composition
  • 00:09:59 - Human milk oligosaccharides help establish the infant gut microbiome
  • 00:16:32 - Omega-3s in breast milk boost brain development
  • 00:18:15 - Vitamins and minerals in breast milk
  • 00:22:05 - Breast milk stem cells and multi-organ microchimerism
  • 00:22:54 - Harmful substances transferred to infants via breast milk
  • 00:28:05 - Breastfeeding boosts the infant's immune system
  • 00:31:17 - Effects on intelligence
  • 00:34:36 - Breastfeeding as a benefit to maternal health

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/breast-milk

Join over 300,000 people and get the latest distilled information on the biology of breast milk straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: breastmilk.mp3
Category:general -- posted at: 4:38pm EST

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the ongoing pandemic and tried to add value by talking about some of the recent research, among other things.

In this episode, you'll discover:

  • 00:00:00 - Introduction
  • 00:04:06 - Data surrounding SARS-CoV-2 duration
  • 00:06:30 - SARS-CoV-2 and long-lasting immunity
  • 00:11:27 - Genetic causes of immune variation
  • 00:14:27 - Previous viral exposure and cross-immunity to SARS-CoV-2
  • 00:18:57 - Antibody-dependent enhancement and SARS-CoV-2 relevance
  • 00:21:50 - Sleep deprivation impairs immunity & vaccine efficacy
  • 00:23:42 - Microbiome composition and immune function
  • 00:28:22 - The differential effects of exercise intensity and duration on immune regulation
  • 00:34:10 - Micronutrient inadequacies promote immune dysregulation
  • 00:46:32 - Effects of sex and age in immune regulation
  • 00:48:59 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
  • 00:52:28 - ARDS and long-term lung damage

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/covid-19-episode-2

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: covid19_qa_2.mp3
Category:general -- posted at: 4:58pm EST

In this episode, Dr. Rhonda Patrick discusses all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

In this episode, you'll discover:

  • 00:00:00 - Introduction
  • 00:07:33 - Background on vitamin C, an antioxidant and immune booster
  • 00:17:09 - Bioavailability of vitamin C and dose frequency
  • 00:22:53 - Vitamin C in the context of the common cold
  • 00:28:09 - Vitamin C improves lung function and immunity
  • 00:35:54 - Vitamin C and exercise - does it blunt exercise adaptation?
  • 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity
  • 00:48:44 - Vitamin C and the brain - memory, learning, and executive function
  • 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection
  • 00:55:33 - Intravenous Vitamin C as an adjunct cancer therapy
  • 00:57:40 - Effect of Vitamin C on fertility and reproduction
  • 00:58:36 - Intravenous vitamin C and cardiovascular health
  • 01:00:42 - Vitamin C and inflammation
  • 01:02:38 - Vitamin C’s mechanisms of action 
  • 01:08:34 - Intravenous and Oral vitamin C safety
  • 01:10:20 - Vitamin C intake and kidney stone risk
  • 01:13:57 - Conclusions

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/vitamin-c

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: vitamin_c.mp3
Category:general -- posted at: 11:48am EST

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon. 

In this episode, you'll discover:

  • 00:00:00 - Introduction
  • 00:02:37 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?
  • 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?
  • 00:17:58 - Can you talk about quercetin's role as a zinc ionophore?
  • 00:20:51 - Is there any indication blood type influences COVID-19 risk?
  • 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?
  • 00:43:45 - Can you discuss whether sauna use might help prevent COVID19?
  • 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19?
  • 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/covid-19-episode-1

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Direct download: covid19_qa_1.mp3
Category:general -- posted at: 5:30pm EST

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, you'll discover:

  • 00:00:00 - Introduction
  • 00:08:00 - Increasing omega-3 levels in the brain with phospholipid DHA
  • 00:27:23 - Metformin's effects on longevity and possible harms
  • 00:48:23 - Fasting and NAD+ supplementation
  • 00:50:05 - Getting sulforaphane from food and supplements 
  • 01:06:57 - Magnesium L-threonate efficacy for brain health
  • 01:13:44 - Sauna use mimics exercise, improving heart and brain health
  • 01:23:48 - New FMF Membership

 

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/rhonda-krs-2

Join over 300,000 people and get the latest distilled information on sulforaphane research straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

 

Direct download: krs_rhonda_2.mp3
Category:general -- posted at: 5:31pm EST

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