Dr. Dominic ("Dom") D'Agostino is an expert on a wide range of topics related to metabolic health, ketosis, and ketogenic diets. As one of the world's foremost experts on the ketogenic diet, Dom has personally practiced some variation of ketogenic diet for over a decade, bringing a substantial amount of practical experience along with his anecdotes from human and animal research.

In this episode, we discuss:

• (00:00) Introduction to Dr. Dominic D'Agostino
• (04:59) What is "keto” (and what it is not)
• (08:42) Types of ketogenic diets
• (15:27) Lifestyle Ketogenic Diet
• (26:36) Biomarkers and hyperlipidemia
• (29:41) Micronutrients and Supplementation
• (33:40) Exogenous Ketones
• (55:48) Optimal blood concentration of ketones (Dom's pick)
• (01:13:31) Exercise performance and anti-catabolic effects
• (01:34:37) Brain and Memory
• (01:42:39) Intermittent Fasting
• (01:51:43) Neurodegenerative Diseases
• (01:58:05) Migraines
• (02:04:17) Autoimmune diseases
• (02:06:15) Cancer
• (02:22:03) Carnivore diet
• (02:28:22) Dom's lifestyle habits
• (02:31:46) Measuring ketones

Watch this episode on YouTube

If you’re interested in learning more, you can read the full show notes

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This episode features a discussion with MedCram co-founder Kyle Allred on the effects of sauna. I had the pleasure of being interviewed by Kyle on all things sauna science and we're posting that discussion for you here. As an exercise mimetic, sauna use has anti-inflammatory, mood-elevating, and detoxifying properties that research increasingly shows may deliver cardiovascular and brain benefits.

The science of sauna use has been a research interest of mine for many years and this discussion is by far one of the most well-rounded discussions I've had on the subject. Thanks to Kyle and MedCram for having me for his interview.

In this episode, we'll discuss:

• (00:00) Introduction
• (02:46) Summary of sauna benefits
• (10:47) Heat as an aerobic exercise mimetic
• (14:45) Effects of heat acclimation on endurance
• (17:37) Why heat shock proteins may protect against dementia
• (23:20) The stress-relieving effects of sauna use (personal anecdote)
• (27:43) Investigating sauna for depression
• (30:32) Brain-derived neurotrophic factor (BDNF) and endorphins response
• (34:51) Cellular repair mechanisms elicited by sauna use
• (40:05) Prevention of muscle atrophy
• (42:45) Detoxification of heavy metals 
• (44:50) Heart rate variability, a measure of stress resilience
• (46:40) The synergy of sauna use and exercise
• (52:13) Cross-cultural and historical prevalence of heat therapy
• (56:12) Infrared sauna vs. traditional saunas
• (58:31) Rhonda's personal sauna protocol: duration, temperature, humidity, and frequency
• (01:03:22) How jacuzzi, hot baths, and hot showers compare to sauna use
• (01:06:19) Hydration, cold therapy, and sauna safety 
• (01:11:18) Who should not use saunas?
• (01:15:21) Does sauna use increase blood sugar levels?
• (01:17:16) Limitations of current sauna research and hopes for future research

MedCram is a YouTube channel created by Kyle Allred, PA-C and Roger Sehuelt, MD, master educators of health and medical science. Their videos cover important topics such as immunity, metabolism, and vitamin D in an authoritative, but approachable way. Visit the MedCram YouTube channel for more efficient, engaging, fun, and lasting way to learn and review medical topics.

Watch this episode on MedCram

If you’re interested in learning more, you can read the full show notes

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Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging.

Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks. 

In this episode, Dr. Levine and I discuss: 

• (00:00) Introduction to Dr. Morgan Levine
• (01:19) What is aging and why does it matter to scientists?
• (04:45) Hallmarks of aging
• (08:59) The advantage of epigenetic clocks in research
• (19:05) Epigenetic age acceleration
• (36:40) Are epigenetic changes in aging a cause or consequence?
• (42:15) Reversing epigenetic age with interrupted reprogramming techniques
• (49:27) Therapeutic plasma exchange in aging and pro-aging factors in blood 
• (56:01) Lifestyle factors that accelerate epigenetic age
• (01:03:23) Reliability of consumer epigenetic aging tests
• (01:06:12) Construct validity of epigenetic clocks
• (01:12:06) Thoughts on most exciting research in aging field 
• (01:13:44) Dr. Levine's lifestyle habits

Looking for more? 
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