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Creatine is renowned for enhancing strength, but its benefits extend far beyond muscle power. In this episode, Dr. Darren Candow, a leading researcher with over 140 peer-reviewed publications, explores creatine’s diverse physiological impacts, from bolstering cognitive resilience under stress to mitigating symptoms of depression and protecting against cognitive decline caused by sleep deprivation. He explains why the conventional dosage of 5 grams per day might be insufficient, and how higher doses (10–25 grams) could unlock additional therapeutic effects.

Timestamps:

• (00:00) Introduction
• (04:34) What makes creatine effective for exercise performance?
• (08:01) The loss of explosive power with aging
• (09:36) How creatine speeds up recovery between sets
• (12:13) Two ways creatine boosts muscle strength
• (14:12) Why creatine might not speed typical weight-training recovery
• (16:38) Anti-catabolic effects
• (17:16) Why do men and women respond differently?
• (18:50) Dietary creatine vs. supplementation
• (19:36) Is creatine supplementation necessary—or optional?
• (21:05) Why plant-based may benefit most
• (22:15) Should creatine dosage change with age?
• (23:01) Loading vs. daily dosing
• (25:57) Why 5 grams might not be enough—other tissues
• (27:48) Can creatine prevent bone loss—even without weight training?
• (28:10) How creatine supports osteoblast activity
• (29:51) Preventing hip fractures with creatine
• (32:33) Creatine vs. bisphosphonates
• (36:21) Why creatine isn’t just for weightlifters
• (38:52) Why stressed brains benefit most
• (40:57) Why brain aging accelerates demand
• (43:54) Why 10g per day might be the optimal dose
• (45:45) Why creatine counteracts sleep deprivation
• (48:53) Before vs. after concussion
• (51:17) Should dosage be adjusted by weight?
• (52:39) Does creatine improve sleep on training days?
• (55:34) Creatine for Alzheimer’s and Parkinson’s—does the science hold up?
• (57:08) Can creatine help with depression and anxiety?
• (1:00:24) The role of creatine and glutamine in preventing respiratory illness
• (1:02:40) Why creatine may enhance endothelial health and circulation
• (1:04:04) Creatine’s role in cardiometabolic health
• (1:05:45) When does loading actually make sense?
• (1:06:51) Creatine’s dual role—preserving muscle and enhancing recovery after injury
• (1:09:46) Is creatine effective without exercise?
• (1:12:01) Why creatine might improve male fertility
• (1:13:57) Is it safe for children?
• (1:17:21) Creatine supplementation during pregnancy
• (1:18:54) Could creatine boost motor skills in kids?
• (1:19:34) Creatine monohydrate vs. the rest
• (1:24:15) How to avoid digestive issues with creatine supplementation
• (1:26:56) Does timing matter—and should you cycle it?
• (1:28:32) Should you take creatine every day—or only workout days?
• (1:29:17) Why caffeine might blunt the effects
• (1:32:21) Does creatine increase body fat—or is that a myth?
• (1:33:08) Preventing cramps (the hydration myth)
• (1:34:33) Understanding the creatinine confusion—why creatine won’t damage your kidneys
• (1:36:59) Why creatine is linked (wrongly?) to baldness
• (1:40:22) Debunking myths—sleep, cancer, urination
• (1:43:39) How creatine affects homocysteine levels
• (1:46:32) Creatine and protein—the ideal post-workout pair?
• (1:49:26) How to pick the best creatine supplement
• (1:51:46) What to know about micronized creatine

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Show notes are available by clicking here

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For decades, exercise was considered an optional part of cancer care—something beneficial for general health but not essential. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes.

With over 600 peer-reviewed studies, Dr. Kerry Courneya's work has fundamentally reshaped our understanding of how structured exercise—whether aerobic, resistance training, or high-intensity intervals—can mitigate treatment side effects, enhance immune function, and directly influence cancer progression.

Timestamps:

• (00:00) Introduction
• (04:31) Why exercise should be effortful
• (05:17) How to meaningfully reduce risk of cancer
• (09:06) What type of exercise is best?
• (10:43) How exercise reduces risk—even for smokers and the obese
• (13:32) Weekend-only exercise
• (16:33) 150 vs. 300 minutes per week (more is better—up to a point)
• (18:47) Why pre-diagnosis exercise matters
• (21:53) Why resilience to cancer treatment starts with exercise
• (23:45) Why low muscle mass drives cancer death
• (26:42) Why BMI fails to measure true obesity
• (30:35) Why daily activity isn't enough (structured exercise matters)
• (32:18) Breaking up sedentary time—do 'exercise snacks' help?
• (34:34) Supplements vs. exercise
• (35:16) Where exercise fits with chemo and immunotherapy
• (38:14) Why rest is not the best medicine
• (44:04) Aerobic vs. resistance
• (44:57) How weight training improves 'chemo completion'
• (47:25) Why exercise creates vulnerability in cancer cells (limitations do apply)
• (49:53) Why exercise might be crucial for tumor elimination
• (55:47) Why cardio may be better at clearing tumor cells
• (59:02) When cancer spreads quickly—and when it doesn't
• (1:00:27) Why liquid biopsies may prevent over-treatment
• (1:05:40) Exercise-sensitive vs. exercise-resistant cancers
• (1:08:50) Prostate cancer therapy—why strength training matters
• (1:10:54) When exercise is the only therapy—does it work?
• (1:12:10) Why HIIT reduces PSA in prostate cancer
• (1:14:24) Avoiding overtreatment—can exercise buy you time?
• (1:14:44) Why high-intensity exercise boosts anti-cancer biology
• (1:15:55) Turning a diagnosis into a wake-up call
• (1:18:55) Why oncologists are rethinking exercise
• (1:21:34) Why exercise eases anxiety about cancer—proven psychological benefits
• (1:27:44) Before, during, and after treatment
• (1:29:46) Why exercise is unique among cancer therapies
• (1:31:00) Why cancer patients stop exercising—the risky mistake almost everyone makes
• (1:33:25) How to get sedentary cancer patients exercising (realistically)
• (1:35:59) The $1 million per patient case for including exercise
• (1:37:40) Why recurrence trials haven't convinced doctors—yet
• (1:40:20) The bottom-line message
• (1:40:39) The myth of a cancer panacea (exercise included)
• (1:46:51) What's the best $50 investment for staying active?
• (1:47:24) Only 15 minutes per day—what's the best anti-cancer exercise?

Show notes are available by clicking here

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