#027 Valter Longo, Ph.D. on the Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

 Dr. Valter Longo

This episode of the FoundMyFitness podcast features Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California.

Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases.

In this podcast, Valter and I discuss...

• (00:00) Introduction
• (03:30) The fasting-mimicking diet makes fasting accessible to more people
• (08:10) Prolonged fasting stimulates stem cell regeneration
• (12:57) Does inflammation cause aging or is it the other way around?
• (17:59) Using the fasting-mimicking diet in a hospital setting
• (22:18) Fasting prior to chemotherapy preps cancer cells for death and protects healthy cells from damage
• (36:05) Using fasting and time-restricted feeding to control weight gain
• (42:08) How long do you need to fast to induce autophagy?
• (45:32) A fasting-mimicking diet reversed a multiple sclerosis-like autoimmune condition in mice
• (52:09) What are the cellular mechanisms that underlie the regenerative benefits of fasting?
• (58:27) Are fasting-mimicking drugs, such as spermidine and resveratrol, safe and effective? What about metformin?
• (01:07:03) Blocking the growth hormone/IGF-1 axis protects from cancer and diabetes in people with Laron's syndrome
• (01:14:23) Exercise is essential for healthy metabolism and longevity

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/valter-longo

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