#070 Dr. Eran Elinav on Microbiome Insights into Personalized Response to Diet, Obesity, and Leaky Gut

Eran Elinav, MD, PhD, is a professor of immunology and principal investigator at the Weizmann Institute of Science in Tel Aviv, Israel, where he co-directs the Personalized Nutrition Project. Dr. Elinav is also a principal investigator at the German Cancer Research Center in Heidelberg, Germany. His research focuses on understanding the complex interactions between humans and the bacteria that reside in their gut and how these interactions shape human health and disease.

In this episode, Dr. Elinav and I discuss...

• (00:00) Introduction to Dr. Eran Elinav
• (06:38) Circadian rhythm of the microbiome
• (17:17) Lessons from Hunter-gatherers
• (24:44) Nurturing the microbiome in children
• (35:16) Triglycerides and cholesterol
• (38:58) Saturated fat
• (40:25) Effect of artificial sweeteners on the microbiome
• (56:10) What causes recurrent obesity
• (58:17) Impact of caloric restriction
• (59:26) Intestinal permeability (gut leakiness)
• (01:19:54) Bacteriophage therapy and precision probiotics
• (01:34:44) Bacterial role in TMAO risk
• (01:40:33) Weight gain from smoking cessation
• (01:41:53) Tips for diet personalization

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