Dr. Rhonda Patrick interviews Wim Hof also known as the "Iceman." Wim holds the world record for the longest ice bath (1 hour and 53 minutes and 12 seconds), just to name one of his many impressive feats. Dr. Patrick and Wim talk a bit about Wim's back story that culminated in him trying out cold water immersion, the relatively recent 2014 scientific publication of the “Wim Hof Method” which includes cold exposure during training, exposure to bacterial endotoxin, Wim's breathing techniques, and meditation ( The 2014 study demonstrated the effects of just 4 days of training with the “Wim Hof method” on 12 volunteers injected with bacterial endotoxin. Some of the effects include: increased epinephrine, norepinephrine, increased anti-inflammatory cytokines (IL-10), decreased pro-inflammatory cytokines (TNF-alpha), increased blood ph to 7.75 (in some cases), and decreased carbon dioxide blood levels. The results of this study hint at some very interesting possibilities that might explain why Wim's technique helps him to endure the cold more, as well as how he was able to suppress his inflammatory response to endotoxin himself.

Direct download: wim_hof_1.mp3
Category:general -- posted at: 3:05am EDT

In this audio recorded Oct. 3rd, 2015, Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). Discussion includes how micronutrient inadequacies are very prevalent, and how her mentor, Dr. Bruce Ames, found that the body does a strategic rationing so that those proteins and enzymes in the body which are essential for short-term survival get their share of vitamins and minerals at the expense of other proteins and enzymes that are essential for long-term survival. This results in insidious types of damage and may lead to diseases of aging such as cancer and neurodegenerative diseases. She also discusses her ongoing clinical research on the role of DNA damage in cancer and aging and how her data shows that obese individuals have much more DNA damage than lean individuals, her recent research on how vitamin D is needed to produce serotonin in the brain and how this may be relevant for the prevention of autism because serotonin shapes the structure and wiring of the developing fetal brain. Finally, she talks about her research on how omega-3 fatty acids regulate serotonin release from neurons and receptor function and how vitamin D and omega-3 fatty acids are important to prevent brain dysfunction particularly in individuals that have gene polymorphisms in the serotonin pathway that predispose them to low serotonin.

Direct download: orthomolecular_congress_1.mp3
Category:general -- posted at: 1:26am EDT